ABSTRACT
Our prospective study included 41 patients, from 13 to 70 years old, and present a nasopharyngeal carcinoma confirmed histologically, during the period going from September 1999 to March 2000, and 45 healthy controls. A blood sample was collected from each patient before any treatment, as well as controls to measure serum LDH and its isoenzymes. Two groups of patients were selected after a period varying from 12 to 37 months with a mean of 29 months: 29 with favourable evolution, 12 with non favourable evolution. The mean serum total LDH and its isoenzymes values were significantly higher in patients than those in controls with values of variable p of 0,001 to 0,05. A significant correlation was found between ganglionnary extension and serum values of total LDH, LDH3 and LDH5. No significant difference were observed between the means serum total LDH before treatment and the clinical evolution of patients. Diagnostic contribution of total LDH is limited, by its ubiquitary character, but could constitute for LDH3 a good marker of the disease progression
Subject(s)
Humans , Male , Female , Nasopharyngeal Neoplasms/blood , Lactate Dehydrogenases/blood , IsoenzymesABSTRACT
The authors report results about three cases of hemoglobinose H descended from the same town in the North East region of Tunisia and being not in way related. Molecular lesions analysis of this type of alpha thalassemia are polymorphic, explaining heterogenity of clinical disorders. The three patients described in this study occurred with a relatively severe symptomatology suspecting not only deletion type defects at the alpha genome level but possible existence of non deletional type defect of alpha 2 gene
Subject(s)
Hemoglobin H , Anemia/pathology , SplenomegalyABSTRACT
In this study, we reported data observed on four adult subjects, homozygous for hemoglobin c and almost exclusively originate from the North-west region of the country. Hemoglobin c -rare abnormality in Tunisia was found at the homozygous state with a symptomatology dominated by splenomegaly. At the hematological level, anemia was observed in 50% of the cases associated with both microcytosis and hypochromia. The implication of this later observation could be the result of iron deficiency
Subject(s)
Humans , Anemia, Iron-Deficiency/complications , SplenomegalyABSTRACT
Hb D Punjab is a hemoglobin abnormality due to the substitution of a glutamic acid by a glutamin on the hemobologin beta chain: beta 121 gLu Gln. Authors report here the first case of this rare variant in a tunisian family